In the previous couple of years, electron microscopy has skilled a brand new methodological paradigm aimed to repair the bottlenecks and overcome the challenges of its analytical workflow. Machine studying and synthetic intelligence are answering this name offering highly effective sources in direction of automation, exploration, and improvement. On this assessment, we consider the state-of-the-art of machine studying utilized to electron microscopy (and obliquely, to supplies and nano-sciences). We begin from the standard imaging strategies to achieve the latest higher-dimensionality ones, additionally masking the latest advances in spectroscopy and tomography. Moreover, the current assessment offers a sensible information for microscopists, and usually for materials scientists, however not essentially superior machine studying practitioners, to straightforwardly apply the supplied set of instruments to their very own analysis. To conclude, we discover the state-of-the-art of different disciplines with a broader expertise in making use of synthetic intelligence strategies to their analysis (e.g., high-energy physics, astronomy, Earth sciences, and even robotics, videogames, or advertising and marketing and funds), as a way to slim down the incoming way forward for electron microscopy, its challenges and outlook.